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ea0035p1099 | Thyroid Cancer | ECE2014

DNMT1 expression in papillary thyroid carcinoma

Brehar Andreea , Procopiuc Camelia , Paun Diana , Manda Dana , Oros Sabina , Caragheorgheopol Andra , Bulgar Alexandra , Brehar Felix , Dumitrescu Cristina , Gherlan Iuliana , Ghemigian Mircea , Stanescu Bogdan , Brasoveanu Daniel , Terzea Dana , Ioachim Dumitru , Plesa Adriana , Huica Irina , Iancu Iulia , Badiu Corin , Dumitrache Constantin

Introduction: In human cancer cells DNMTs are responsible for both de novo and maintenance methylation of tumor suppressor genes. Many studies have analyzed the relationship between the altered expression of DNMT1 and DNA methylation in cancer.Aim: To analyze DNMT1 expression in thyroid papillary carcinoma.Design: 49 patients aged 10–82 years hospitalized for thyroidectomy were included between January 2013 and July 2...
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ea0035p1100 | Thyroid Cancer | ECE2014

Methylation status of HOXB4 gene in papillary thyroid carcinoma

Brehar Andreea , Procopiuc Camelia , Paun Diana , Manda Dana , Oros Sabina , Caragheorgheopol Andra , Bulgar Alexandra , Brehar Felix , Plesa Adriana , Iancu Iulia , Botezatu Anca , Ghemigian Mircea , Stanescu Bogdan , Brasoveanu Daniel , Terzea Dana , Ioachim Dumitru , Dumitrescu Cristina , Gherlan Iuliana , Badiu Corin , Dumitrache Constantin

Introduction: HOXB4 functions as a transcription factor involved in cell differentiation during embryogenesis and plays a role in apoptosis.Aim: This study analyzed HOXB4 methylation status in thyroid papillary carcinoma.Method: 54 patients aged 10–82 years hospitalized for thyroidectomy were included between January 2013 and July 2013. The inclusion criterion was patients with thyroid nodules with indication for surgery and t...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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